HuagongsheHuagongshe Chemistry Print Report · For research reference only
Geranylgeraniol → (2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-yl pyridin-4-ylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Geranylgeraniol | HCID 5281365 | — |
| Reactant | 4-Isocyanatopyridine | HCID 11636796 | — |
| Reactant | O-((2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-yl) pyridin-3-ylcarbamothioate | HCID 86701128 | — |
| Product | (2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-yl pyridin-4-ylcarbamate | HCID 71735434 | 3% |
Reaction Steps
Similar to the preparation of 38a, the reaction of alcohol 1 with 4-pyridyl isocyanate afforded the desired compound 39 in 3% yield (10 mg) as a viscous oil. Column (DCM/MeOH); TLC Rf: 0.34 (10% MeOH/DCM); LCMS: MS (m/z): 411 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09045403B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-d983189f62e34ff3978f07161012d7f4 |
| Source note | uspto-grants-2015_06 |