HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Benzothiophene-3-carbaldehyde → HCID 136272166, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Benzothiophene-3-carbaldehyde | HCID 227328 | — |
| Reactant | 2-Amino-5-(piperidin-1-yl)benzamide | HCID 10727606 | — |
| Product | HCID 136272166 | HCID 136272166 | — |
Reaction Steps
Compound 28 was synthesized from 5-piperidinyl-2-aminobenzamide (12) (1.6 g, 7.3 mmol) and thianaphthene-3-carboxaldehyde (16) (1.2 g, 7.3 mmol): yield 1.6 g (60%); pale yellow crystals; mp>300° C.; 1H NMR (DMSO-d6) δ 1.57-1.59 (6H, m, (CH2)2CH2NCH2CH2), 3.22-3.25 (4H, m, CH2NCH2), 7.42-7.54 (4H, m, 4×ArH), 7.63-7.67 (1H, m, 1×ArH), 8.03-8.07 (1H, m, 1×ArH), 8.66 (1H, s, 1×ArH), 8.97-9.00 (1H, m, 1×ArH), 12.30 (1H, br s, NH) ppm; MS (ESI) m/z 361; Anal. (C21H19N3OS): C, H, N.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09045437B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-0d37ab7f5aa14a8688a677d1fb68b28c |
| Source note | uspto-grants-2015_06 |