3,4-Difluoroaniline → HCID 66625640, compound

HRID 2167247Notes

Reaction equation

HRID 2167247 reaction equation
[C:1]([N:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C@@H:7]([OH:14])[CH2:6][C@@H:5]1[CH3:15])(=[O:3])[CH3:2].[F:16][C:17]1[CH:18]=[C:19]([CH:21]=[CH:22][C:23]=1[F:24])N>>[C:1]([N:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C@H:7]([O:14][C:21]2[CH:19]=[CH:18][C:17]([F:16])=[C:23]([F:24])[CH:22]=2)[CH2:6][C@@H:5]1[CH3:15])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 774693,4-DifluoroanilineHCID 66626005HCID 66626005, compound

Product 1

HCID 66625640HCID 66625640, compoundYield 64%

Procedure

A compound was produced in the same manner as in Example 12, using 60 mg of trans-1-acetyl-4-hydroxy-2-methyl-1,2,3,4-tetrahydroquinoline and 112 mg of 3,4-difluoroaniline, and thus 59 mg (64%) of the title compound was obtained as a colorless oily substance.

Workup

  1. customA compound was produced in the same manner as in Example 12

Sources & evidence

ORD record
ord-8f21717ce06b4672aba9c9d9dc62e42f
Source dataset
uspto-grants-2015_06
Patent number
US09045423B2

Reaction notes

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