Phenol → HCID 66625178, compound

HRID 2167250Notes

Reaction equation

HRID 2167250 reaction equation
[C:1]([N:4]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([F:14])[CH:12]=2)[C@@H:7]([OH:15])[CH2:6][C@@H:5]1[CH3:16])(=[O:3])[CH3:2].[C:17]1(O)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[C:1]([N:4]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([F:14])[CH:12]=2)[C@H:7]([O:15][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:6][C@@H:5]1[CH3:16])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 996PhenolHCID 66626015HCID 66626015, compound

Product 1

HCID 66625178HCID 66625178, compoundYield 26.1%

Procedure

(Step 4) A compound was produced in the same manner as in Example 2, using 100 mg of trans-1-acetyl-7-fluoro-4-hydroxy-2-methyl-1,2,3,4-tetrahydroquinoline and 84 mg of phenol, and thus 35 mg (26%) of the title compound was obtained as a white solid.

Workup

  1. custom(Step 4) A compound was produced in the same manner as in Example 2

Sources & evidence

ORD record
ord-052765a5e0e74e68ab9fcae174df643f
Source dataset
uspto-grants-2015_06
Patent number
US09045423B2

Reaction notes

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