2-Fluoroaniline → HCID 66625250, compound

HRID 2167251Notes

Reaction equation

HRID 2167251 reaction equation
F[C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1N.[C:9]([N:12]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][C:20]=2[F:22])[C@H:15]([OH:23])[CH2:14][C@@H:13]1[CH3:24])(=[O:11])[CH3:10]>>[C:9]([N:12]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][C:20]=2[F:22])[C@H:15]([O:23][C:2]2[CH:8]=[CH:7][CH:6]=[CH:5][CH:3]=2)[CH2:14][C@@H:13]1[CH3:24])(=[O:11])[CH3:10]

Participants

3

Reactant 2

HCID 95842-FluoroanilineHCID 66625326HCID 66625326, compound

Product 1

HCID 66625250HCID 66625250, compoundYield 39%

Procedure

Cis-1-acetyl-8-fluoro-4-hydroxy-2-methyl-1,2,3,4-tetrahydroquinoline was obtained in the same manner as in Example 17, using 2-fluoroaniline. A compound was produced in the same manner as in Example 1, using 100 mg of cis-1-acetyl-8-fluoro-4-hydroxy-2-methyl-1,2,3,4-tetrahydro quinoline, and thus 52 mg (39%) of the title compound was obtained as a white solid.

Workup

  1. customA compound was produced in the same manner as in Example 1

Sources & evidence

ORD record
ord-5bc5f252b8d54a38a7fc1bea10bed037
Source dataset
uspto-grants-2015_06
Patent number
US09045423B2

Reaction notes

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