Phenol → HCID 66625284, compound

HRID 2167253Notes

Reaction equation

HRID 2167253 reaction equation
[C:1]([N:4]1[C:13]2[C:8](=[CH:9][C:10]([F:14])=[CH:11][CH:12]=2)[C@H:7]([OH:15])[CH2:6][C@@H:5]1[CH3:16])(=[O:3])[CH3:2].[C:17]1(O)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[C:1]([N:4]1[C:13]2[C:8](=[CH:9][C:10]([F:14])=[CH:11][CH:12]=2)[C@H:7]([O:15][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:6][C@@H:5]1[CH3:16])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 996PhenolHCID 66624905HCID 66624905, compound

Product 1

HCID 66625284HCID 66625284, compoundYield 63%

Procedure

A compound was produced in the same manner as in Example 12, using 39 mg of cis-1-acetyl-6-fluoro-4-hydroxy-2-methyl-1,2,3,4-tetrahydro quinoline and phenol, and thus 33 mg (63%) of the title compound was obtained as a white solid.

Workup

  1. customA compound was produced in the same manner as in Example 12

Sources & evidence

ORD record
ord-20c65c57b8e14c6e937a9243ff1ee1c7
Source dataset
uspto-grants-2015_06
Patent number
US09045423B2

Reaction notes

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