tert-Butyl 12-amino-4,7,10-trioxadodecanoate → HCID 66626164, compound

HRID 2167273Notes

Reaction equation

HRID 2167273 reaction equation
[C:1]([N:4]1[C:13]2[C:8](=[CH:9][C:10]([C:14]([OH:16])=O)=[CH:11][CH:12]=2)[CH:7]([NH:17][C:18]2[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=2)[CH2:6][C@@H:5]1[CH3:25])(=[O:3])[CH3:2].[NH2:26][CH2:27][CH2:28][O:29][CH2:30][CH2:31][O:32][CH2:33][CH2:34][O:35][CH2:36][CH2:37][C:38]([O:40][C:41]([CH3:44])([CH3:43])[CH3:42])=[O:39]>>[C:1]([N:4]1[C:13]2[C:8](=[CH:9][C:10]([C:14]([NH:26][CH2:27][CH2:28][O:29][CH2:30][CH2:31][O:32][CH2:33][CH2:34][O:35][CH2:36][CH2:37][C:38]([O:40][C:41]([CH3:44])([CH3:43])[CH3:42])=[O:39])=[O:16])=[CH:11][CH:12]=2)[C@H:7]([NH:17][C:18]2[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=2)[CH2:6][C@@H:5]1[CH3:25])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 16218573tert-Butyl 12-amino-4,7,10-trioxadodecanoateHCID 66624842HCID 66624842, compound

Product 1

HCID 66626164HCID 66626164, compoundYield 102.1%

Procedure

Reactions and treatments were carried out in the same manner as in Example 110, using 29 mg of (2S)-1-acetyl-4-[(4-chlorophenyl)amino]-2-methyl-1,2,3,4-tetrahydroquinoline-6-carboxylic acid and 44 mg of tert-butyl 12-amino-4,7,10-trioxadodecanoate. Thus, 51 mg (100%) of the title compound was obtained as a colorless oily substance.

Sources & evidence

ORD record
ord-5e7c72f0817f4542bca04c2dd8108ba8
Source dataset
uspto-grants-2015_06
Patent number
US09045423B2

Reaction notes

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