Ammonia → HCID 46932746, compound

Participants

Reaction Steps

Reactions and treatments were carried out in the same manner as in Example 118, using 104.8 mg of (2S,4R)-1-acetyl-2-methyl-4-{[4-(tetrahydro-2H-pyran-4-yl)phenyl]amino}-1,2,3,4-tetrahydroquinoline-6-carboxylic acid instead of (2S,4R)-1-acetyl-2-methyl-4-(4-morpholinophenoxy)-1,2,3,4-tetrahydroquinoline-6-carboxylic acid, and using aqueous ammonia instead of monomethylamine. Thus, 70.5 mg (67.3%, cis:trans=9:1) of the title compound was obtained as a white crystalline powder.

Provenance & Evidence