3-(Morpholin-4-yl)aniline → HCID 66625577, compound

HRID 2167289Notes

Reaction equation

HRID 2167289 reaction equation
[C:1]([N:4]1[C:13]2[C:8](=[CH:9][C:10]([C:14]([O:16]CC)=[O:15])=[CH:11][CH:12]=2)[C:7](=O)[CH2:6][C@@H:5]1[CH3:20])(=[O:3])[CH3:2].[O:21]1[CH2:26][CH2:25][N:24]([C:27]2[CH:28]=[C:29]([CH:31]=[CH:32][CH:33]=2)[NH2:30])[CH2:23][CH2:22]1>>[C:1]([N:4]1[C:13]2[C:8](=[CH:9][C:10]([C:14]([OH:16])=[O:15])=[CH:11][CH:12]=2)[C@H:7]([NH:30][C:29]2[CH:31]=[CH:32][CH:33]=[C:27]([N:24]3[CH2:25][CH2:26][O:21][CH2:22][CH2:23]3)[CH:28]=2)[CH2:6][C@@H:5]1[CH3:20])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 8477683-(Morpholin-4-yl)anilineHCID 66624941HCID 66624941, compound

Product 1

HCID 66625577HCID 66625577, compoundYield 32%

Procedure

Reactions and treatments were carried out in the same manner as in Example 2, using ethyl (2S)-1-acetyl-4-oxo-2-methyl-1,2,3,4-tetrahydroquinoline-6-carboxylate and 3-morpholinoaniline, and subsequently, hydrolysis of the ester was carried out by a known method. Thus, 70 mg (32%) of the title compound was obtained as a light orange-colored powder.

Sources & evidence

ORD record
ord-f8dd3858537c4273917cc198aad575d6
Source dataset
uspto-grants-2015_06
Patent number
US09045423B2

Reaction notes

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