Sodium Hydroxide → HCID 178496237, compound

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Reaction Steps

To a solution of methyl 2-(2-hydroxy-4-(2-(2-methoxyethoxy)ethoxy)phenyl)-4-methyl-4,5-dihydro-1H-imidazole-4-carboxylate (0.17 g, 0.5 mmol) in MeOH (5 mL) was added NaOH (40 mg, 1.0 mmol) and water (one drop). The resulting solution was stirred for 2 h at room temperature. The solvent was evaporated under vacuum and the residue was purified by Combi Flash to obtain the title compound as colorless oil (100 mg, 60%). 1H NMR (300 MHz, CD3OD, n=2): δ 7.65-7.85 (m, 1H), 6.55-6.75 (m, 2H), 4.30-4.40 (m, 1H), 4.10-4.30 (m, 2H), 3.70-3.95 (m, 2H), 3.65-3.70 (m, 2H), 3.55-3.65 (m, 2H), 3.33 (s, 3H), 1.74 (s, 3H). LC-MS (ES, m/z): 339 [M+H]+.

Provenance & Evidence