Sodium Hydroxide → HCID 178496239, compound

Participants

Reaction Steps

To a solution of methyl 2-(2-hydroxy-3-(2-(2-methoxyethoxy)ethoxy)phenyl)-4-methyl-4,5-dihydro-1H-imidazole-4-carboxylate (0.85 g, 0.25 mmol) in MeOH (5 mL) was added NaOH (20 mg, 0.5 mmol) and water (one drop). The resulting mixture was stirred for 2 h at room temperature. The solvent was evaporated under vacuum and the residue was purified by Combi Flash to obtain the title compound as colorless oil (50 mg, 60%). 1H NMR (300 MHz, CD3OD, n=2): δ 7.40-7.50 (m, 1H), 7.10-7.25 (m, 1H), 6.75-6.95 (m, 1H), 4.30-4.40 (m, 1H), 4.15-4.25 (m, 2H), 3.75-3.95 (m, 2H), 3.45-3.75 (m, 5H), 3.35 (s, 3H), 1.67 (s, 3H). LC-MS (ES, m/z): 339 [M+H]+.

Provenance & Evidence