Boron tribromide → HCID 58506493, compound

Participants

Reaction Steps

To a solution of methyl 1-(2,4-dimethoxyphenyl)-1H-pyrazole-3-carboxylate 2 (1.00 g, 3.82 mmol, 1.00 equiv) in DCM (20 mL) was added BBr3 (9.55 g, 38.2 mmol, 10 equiv) at −40° C. The resulting solution was stirred overnight at room temperature. The mixture was quenched by the addition of 10 mL of water and the reaction mixture was extracted with 3×200 mL of ethyl acetate. The combined organic layers were washed with 200 mL of brine, dried over anhydrous sodium sulfate and concentrated under vacuum. This resulted in 0.8 g (90%) of methyl 1-(2,4-dihydroxyphenyl)-1H-pyrazole-3-carboxylate 3 as a white solid. LC-MS: m/z=235 (MH)+.

Provenance & Evidence