Diethylene Glycol Monomethyl Ether → HCID 58506478, compound

Participants

Reaction Steps

To a solution of methyl 1-(2,4-dihydroxyphenyl)-1H-pyrazole-3-carboxylate 3 (200 mg, 0.855 mmol, 1.00 equiv) in THF (5 mL), 2-(2-methoxyethoxy)ethanol (103 mg, 0.855 mmol, 1.00 equiv) was added Ph3P (223 mg, 0.855 mmol, 1.00 equiv), and DEAD (149 mg, 0.855 mmol, 1.00 equiv) at 0° C. The resulting solution was stirred overnight. The solvent was concentrated under vacuum, the residue was applied onto a silica gel column and eluted with PE/EA (1/1). This resulted in 70 mg (50%) of methyl 1-(2-hydroxy-4-(2-(2-methoxyethoxy)ethoxy)phenyl)-1H-pyrazole-3-carboxylate 4 as a green oil.

Provenance & Evidence