Hydroxylamine → HCID 43188223, compound

Participants

Reaction Steps

4-(4-Methoxyphenoxy)benzonitrile (581 mg, 2.58 mmol) was dissolved in ethanol (10.0 mL) and hydroxylamine (630 μL, 10.32 mmol) was added. The mixture was refluxed for 1 hour and the reaction was cooled and then concentrated in vacuo to give the crude product which was taken to the next step without further purification (636 mg, 95%). 1H NMR (500 MHz, CDCL3) δ(ppm): 3.81 (1H, s), 4.87 (1H, bs), 6.88-6.94 (4H, m), 6.99 (2H, d, J=9.2 Hz), 7.55 (2H, d, J=9.0 Hz). 13C NMR (125 MHz, CDCL3) δ(ppm): 55.8 (CH3), 115.2 (CH), 117.4 (CH), 121.4 (CH), 126.6 (CH), 127.6, 149.5, 152.5, 156.5, 160.4. MS (FAB+): 259 (MH+). HRMS for C14H14N2O3 (MH+): calculated: 259.1083; found 259.1100.

Provenance & Evidence