HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → tert-Butyl piperazine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Sulfuryl chloride | HCID 24648 | — |
| Reactant | Trimethylsilyl cyanide | HCID 82115 | — |
| Reactant | Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) | HCID 466102 | — |
| Reactant | (cyano-C)diethylaluminium | HCID 16683962 | — |
| Catalyst | zinc(II)iodide | HCID 9883512 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Toluene | HCID 1140 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Solvent | Diethyl ether methanol | HCID 21864698 | — |
| Product | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
Reaction Steps
Conditions: K1) Na2S2O5 or PPTS, H2O, CH3CN; K2) TMSCN, ZnI2, Et2O/CH3OH; K3) Et2AlCN, Ti(i-PrO)4, toluene; L) TFA, CH2Cl2; M) sulfonyl chloride, Et3N, CH2Cl2
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09045445B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-a722dfb062cb4155b2dc5bbc40b0f71d |
| Source note | uspto-grants-2015_06 |