HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4-Bromophenyl)boronic acid → 3-(4-{[1-(4-Bromophenyl)-3-(trifluoromethyl)-1H-pyrrol-2-yl]methoxy}-2,3-dimethylphenyl)propan-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4-Bromophenyl)boronic acid | HCID 79599 | — |
| Reactant | Ethyl 3-(4-hydroxy-2,3-dimethylphenyl)propanoate | HCID 58566491 | — |
| Reactant | methyl 3-(trifluoromethyl)-1H-pyrrole-2-carboxylate | HCID 90405535 | — |
| Product | 3-(4-{[1-(4-Bromophenyl)-3-(trifluoromethyl)-1H-pyrrol-2-yl]methoxy}-2,3-dimethylphenyl)propan-1-ol | HCID 90406588 | — |
Reaction Steps
The title compound was prepared by (a) reacting the product prepared in Step B of Example 1 and 4-bromophenylboronic acid according to the procedure described in Example 1, Step C, (b) then reacting the resulting product according to the procedure in Example 1, Step D, (c) then reacting the resulting product with ethyl 3-(2,3-dimethyl-4-hydroxyphenyl)propanoate according to the procedure in Example 1, Step E, and Example 2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09045454B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-1b5f96bf2ccd4bf994f35e434743af6a |
| Source note | uspto-grants-2015_06 |