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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2167375Generated: October 25, 2026

(4-Bromophenyl)boronic acid → 3-(4-{[1-(4-Bromophenyl)-3-(trifluoromethyl)-1H-pyrrol-2-yl]methoxy}-2,3-difluorophenyl)propanoic acid

https://huagongshe.com/reaction/2167375

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(4-Bromophenyl)boronic acidHCID 79599—
ReactantEthyl 3-(2,3-difluoro-4-hydroxyphenyl)propanoateHCID 90404786—
Reactantmethyl 3-(trifluoromethyl)-1H-pyrrole-2-carboxylateHCID 90405535—
Product3-(4-{[1-(4-Bromophenyl)-3-(trifluoromethyl)-1H-pyrrol-2-yl]methoxy}-2,3-difluorophenyl)propanoic acidHCID 90406550—

Reaction Steps

The title compound was prepared by (a) reacting the product prepared in Step B of Example 1 and 4-bromophenylboronic acid according to the procedure described in Example 1, Step C, (b) then reacting the resulting product according to the procedure in Example 1, Step D, and (c) then reacting the resulting product with ethyl 3-(2,3-difluoro-4-hydroxyphenyl)propanoate according to the procedure described in Example 1, Steps E and F.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09045454B2
Source datasetuspto-grants-2015_06
ORD IDord-46d6c91096c84033ae2a4c5c6462b9a3
Source noteuspto-grants-2015_06