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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2167378Generated: October 25, 2026

(4-Methoxyphenyl)boronic acid → 3-(4-{[1-(4-Methoxyphenyl)-3-(trifluoromethyl)-1H-pyrrol-2-yl]methoxy}-2,3-dimethylphenyl)propanoic acid

https://huagongshe.com/reaction/2167378

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(4-Methoxyphenyl)boronic acidHCID 201262—
ReactantEthyl 3-(4-hydroxy-2,3-dimethylphenyl)propanoateHCID 58566491—
Reactantmethyl 3-(trifluoromethyl)-1H-pyrrole-2-carboxylateHCID 90405535—
Product3-(4-{[1-(4-Methoxyphenyl)-3-(trifluoromethyl)-1H-pyrrol-2-yl]methoxy}-2,3-dimethylphenyl)propanoic acidHCID 90406548—

Reaction Steps

The title compound was prepared by (a) reacting the product prepared in Step B of Example 1 and 4-methoxyphenylboronic acid according to the procedure described in Example 1, Step C, (b) then reacting the resulting product according to the procedure in Example 1, Step D, and (c) then reacting the resulting product with ethyl 3-(2,3-dimethyl-4-hydroxyphenyl)propanoate according to the procedures described in Example 1, Steps E and F.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09045454B2
Source datasetuspto-grants-2015_06
ORD IDord-b0c0b049b0994f8d9fcc0ff5ce8e4278
Source noteuspto-grants-2015_06