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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2167380Generated: October 25, 2026

(4-Methoxyphenyl)boronic acid → 3-(2,3-Difluoro-4-{[1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrrol-2-yl]methoxy}phenyl)propanoic acid

https://huagongshe.com/reaction/2167380

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(4-Methoxyphenyl)boronic acidHCID 201262—
ReactantEthyl 3-(2,3-difluoro-4-hydroxyphenyl)propanoateHCID 90404786—
Reactantmethyl 3-(trifluoromethyl)-1H-pyrrole-2-carboxylateHCID 90405535—
Product3-(2,3-Difluoro-4-{[1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrrol-2-yl]methoxy}phenyl)propanoic acidHCID 90406129—

Reaction Steps

The title compound was prepared by (a) reacting the product prepared in Step B of Example 1 and 4-methoxyphenylboronic acid according to the procedure described in Example 1, Step C, (b) then reacting the resulting product according to the procedure in Example 1, Step D, and (c) then reacting the resulting product with ethyl 3-(2,3-difluoro-4-hydroxyphenyl)propanoate according to the procedure described in Example 1, Steps E and F.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09045454B2
Source datasetuspto-grants-2015_06
ORD IDord-e563ed376a504549836b4b492b1d5027
Source noteuspto-grants-2015_06