(4-Methoxyphenyl)boronic acid → 3-(2,3-Difluoro-4-{[1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrrol-2-yl]methoxy}phenyl)propan-1-ol

Participants

Role	Name	HCID	Charge
Reactant	(4-Methoxyphenyl)boronic acid	HCID 201262	—
Reactant	Ethyl 3-(2,3-difluoro-4-hydroxyphenyl)propanoate	HCID 90404786	—
Reactant	methyl 3-(trifluoromethyl)-1H-pyrrole-2-carboxylate	HCID 90405535	—
Product	3-(2,3-Difluoro-4-{[1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrrol-2-yl]methoxy}phenyl)propan-1-ol	HCID 90407412	—

Reaction Steps

The title compound was prepared by (a) reacting the product prepared in Step B of Example 1 and 4-methoxyphenylboronic acid according to the procedure described in Example 1, Step C, (b) then reacting the resulting product according to the procedure in Example 1, Step D, (c) then reacting the resulting product with ethyl 3-(2,3-difluoro-4-hydroxyphenyl)propanoate according to the procedure described in Example 1, Step E, and Example 2.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09045454B2
Source dataset	uspto-grants-2015_06
ORD ID	ord-4dff20feb12343d589eb58c5cdc3bae1
Source note	uspto-grants-2015_06