Methyl pyrrole-2-carboxylate → HCID 90407037, compound

HRID 2167384Notes

Reaction equation

HRID 2167384 reaction equation
[NH:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([O:8][CH3:9])=O.[CH2:10]([C:12]1[CH:17]=[CH:16][C:15](B(O)O)=[CH:14][CH:13]=1)[CH3:11].[CH3:21][C:22]1[C:27](C)=[C:26](O)[CH:25]=[CH:24][C:23]=1[CH2:30][CH2:31][C:32]([O:34]CC)=[O:33]>>[CH2:10]([C:12]1[CH:17]=[CH:16][C:15]([N:1]2[CH:5]=[CH:4][CH:3]=[C:2]2[CH2:6][O:8][C:9]2[CH:25]=[CH:24][C:23]([CH2:30][CH2:31][C:32]([OH:34])=[O:33])=[C:22]([CH3:21])[C:27]=2[CH3:26])=[CH:14][CH:13]=1)[CH3:11]

Participants

4

Reactant 3

HCID 136930Methyl pyrrole-2-carboxylateHCID 2734352Boronic acid, (4-ethylphenyl)-HCID 58566491Ethyl 3-(4-hydroxy-2,3-dimethylphenyl)propanoate

Product 1

HCID 90407037HCID 90407037, compound

Procedure

The title compound was prepared by reacting methyl 1H-pyrrole-2-carboxylate with 4-ethylphenylboronic acid according to the procedures of Example 1, Steps C and D, then reacting the resulting product with ethyl 3-(2,3-dimethyl-4-hydroxyphenyl)propanoate according to the procedures described in Example 1, Steps E and F.

Sources & evidence

ORD record
ord-eb77397c2d9041d9aacc61a8f35c67e0
Source dataset
uspto-grants-2015_06
Patent number
US09045454B2

Reaction notes

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