Formaldehyde → HCID 59392825, compound

Participants

Reaction Steps

A solution of 8-[4-(1,1-Dioxido-thiomorpholin-4-ylmethyl)-3,5-difluoro-phenyl]-2-(3-piperazin-1-yl-phenyl)-quinoxaline (as obtained in example 169, 79 mg, 0.137 mmol) in MeOH (3 ml) and CH2Cl2 (1.5 ml) is treated with HCHO (41 μl, 0.550 mmol, 37% in H2O/MeOH 9:1) and NaBH3CN (35 mg, 0.546 mmol) at RT for 2 h. The reaction mixture is concentrated under reduced pressure. The residue is purified by reverse phase prep-HPLC (Waters) to afford the title compound as a yellow solid.

Provenance & Evidence