HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → Methyl 3-aminocarbonyl-2-chloro-4-methylsulfonylbenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Methyl 2-chloro-3-chlorocarbonyl-4-methylsulfonylbenzoate | HCID 18517408 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | Methyl 3-aminocarbonyl-2-chloro-4-methylsulfonylbenzoate | HCID 22114953 | — |
Reaction Steps
Ammonia was passed for 2 hours into a solution of 15.0 g (48 mmol) of methyl 2-chloro-3-chlorocarbonyl-4-methylsulfonylbenzoate and 300 ml of dry dioxane. The precipitate formed was filtered off with suction and the filtrate was concentrated. This gave 15.2 g of methyl 3-aminocarbonyl-2-chloro-4-methylsulfonylbenzoate in quantitative yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09045465B1 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-b8165133d8d941fd944499c51ecbe846 |
| Source note | uspto-grants-2015_06 |