Benzaldehyde → (Z)-tert-Butyl-7-(1-cyano-2-phenylvinyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Participants

Reaction Steps

To a solution of 0.231 mmol tert-butyl-7-(cyanomethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate in 2 ml ethanol were added 0.278 mmol of NaOEt solution (21%) and 0.254 mmol benzaldehyde. The mixture was stirred at room temperature over night. The mixture was diluted with ethanol and H2O, and a white precipitation observed. The solid was filtered off and washed with ethanol and H2O. The white solid was dissolved in methanol. Evaporation of the solvent gave 64 mg (77%) of solid material.

Provenance & Evidence