4-Fluoro-2-nitro-1-propoxybenzene → 5-Fluoro-2-propoxyaniline

HRID 2167456Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2167456
[F:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:9][CH2:10][CH3:11])=[C:4]([N+:12]([O-])=O)[CH:3]=1>[C].[Pd].C(O)C>[F:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:9][CH2:10][CH3:11])=[C:4]([CH:3]=1)[NH2:12]

Komponenten

4

Edukt 1

HCID 669171744-Fluoro-2-nitro-1-propoxybenzene

Produkt 1

HCID 261896335-Fluoro-2-propoxyanilineAusbeute 86 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

4-Fluoro-2-nitro-1-propoxybenzene (2.0 g, 10.0 mmol) and 5% palladium carbon (750 mg) were added to ethanol (30 ml). Catalytic reduction was conducted at room temperature and atmospheric pressure (normal pressure). The catalyst was removed by celite filtration, and the filtrate was concentrated under reduced pressure. The residue was dissolved in dichloromethane, and dried over anhydrous magnesium sulfate. The resulting dry product was concentrated under reduced pressure to thereby obtain 1.45 g of oily red orange 5-fluoro-2-propoxyaniline (yield: 86%).

Aufarbeitung

  1. customwas conducted at room temperature
  2. customThe catalyst was removed by celite filtration
  3. concentrationthe filtrate was concentrated under reduced pressure
  4. dissolutionThe residue was dissolved in dichloromethane
  5. dry with materialdried over anhydrous magnesium sulfate
  6. concentrationThe resulting dry product was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-d7faf677e2ee4ac080ffcec65e377450
Quelldatensatz
uspto-grants-2015_06
Patentnummer
US09045464B2

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