HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 57481178, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | HCID 58119301 | HCID 58119301 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 57481178 | HCID 57481178 | — |
Reaction Steps
To a solution of 2-[5-(2-pyridin-2-yl-1,3-oxazol-4-yl)pyridin-2-yl]propan-2-ol from Step D (75 mg, 0.267 mmol) in DCM (1 mL) was added NBS (62 mg, 0.347 mmol). The reaction mixture was stirred at rt for 16 h. Water was added and the mixture extracted with DCM. The organics were dried (MgSO4), and concentrated to afford 2-[5-(5-bromo-2-pyridin-2-yl-1,3-oxazol-4-yl)pyridin-2-yl]propan-2-ol, which was used without further purification LCMS: m/z 360.0 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09045467B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-39a2d4dd1e5a41be931e182b12cfda42 |
| Source note | uspto-grants-2015_06 |