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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2167485Generated: October 31, 2026

Water → HCID 57481178, compound

https://huagongshe.com/reaction/2167485

Reaction equation

Participants

RoleNameHCIDCharge
ReactantWaterHCID 962—
ReactantN-bromobutanimideHCID 67184—
ReactantHCID 58119301HCID 58119301—
SolventDichloromethaneHCID 6344—
ProductHCID 57481178HCID 57481178—

Reaction Steps

To a solution of 2-[5-(2-pyridin-2-yl-1,3-oxazol-4-yl)pyridin-2-yl]propan-2-ol from Step D (75 mg, 0.267 mmol) in DCM (1 mL) was added NBS (62 mg, 0.347 mmol). The reaction mixture was stirred at rt for 16 h. Water was added and the mixture extracted with DCM. The organics were dried (MgSO4), and concentrated to afford 2-[5-(5-bromo-2-pyridin-2-yl-1,3-oxazol-4-yl)pyridin-2-yl]propan-2-ol, which was used without further purification LCMS: m/z 360.0 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09045467B2
Source datasetuspto-grants-2015_06
ORD IDord-39a2d4dd1e5a41be931e182b12cfda42
Source noteuspto-grants-2015_06