Acetonitrile → HCID 131732908, compound

Participants

Reaction Steps

To the product from Step B (19 mg, 43 mmol) acetonitrile (0.5 mL) was added L-tartaric acid (6.5 mg, 43 mmol) in water (2 mL). The resultant solution was lyophilized for 48 hours to give 6-(5-(3-chloro-4-fluorophenyl)-1,3,4,5-tetrahydro-2,5-ethanobenzo[c]azepin-8-yl)-N-methylpyridazine-3-carboxamide, L-tartrate salt (22 mg, 98%, HPLC: 98.8%) as an off-white solid: 1H NMR (400 MHz, CD3OD): δ 8.32 (m, 2H), 8.16 (s, 1H), 7.91 (d, J=8.0 Hz, 1H), 7.53 (d, J=7.2 Hz, 1H), 7.37 (m, 2H), 6.62 (d, J=8.4 Hz, 1H), 4.95 (m, 2H), 4.46 (s, 2H), 3.65-3.34 (m, 4H), 3.06 (s, 3H), 2.84 (m, 2H), 2.50 (m, 2H). ESI MS (m/z): 437 [M′+1].

Provenance & Evidence