Trifluoroacetic acid → HCID 49838644, compound

Participants

Reaction Steps

2-(4-(2-(5-amino-8-methylbenzo[f][1,7]naphthyridin-2-yl)ethyl)-3-methylphenoxy)ethylphosphonic acid (22) was prepared according to the procedure described in Example 1—Step 3, but using diethyl 2-(4-(2-(5-amino-8-methylbenzo[f][1,7]naphthyridin-2-yl)ethyl)-3-methylphenoxy)ethylphosphonate from the previous step 2. TFA was added to the 1H NMR sample to solubilize the compound for analysis. The 1H NMR (dimethyl sulfoxide) obtained for 2-(4-(2-(5-amino-8-methylbenzo[f][1,7]naphthyridin-2-yl)ethyl)-3-methylphenoxy)ethylphosphonic acid (22) was: δ 8.83 (s, 1H), 8.71 (s, 1H), 8.35 (d, 1H, J=8.3 Hz), 7.35 (s, 1H), 7.15 (d, 1H, J=9.6 Hz), 7.08 (d, 1H, J=8.4 Hz), 7.06-7.03 (br, 2H) 6.71 (s, 1H), 6.64 (d, 1H, J=8.1 Hz), 4.09-3.99 (m, 2H), 3.07 (t, 2H, J=6.9), 2.93 (t, 2H, J=6.7), 2.44 (s, 3 H), 2.26 (s, 3H), 1.72-1.62 (m, 2H). LRMS [M+H]=452.2

Provenance & Evidence