HCID 90427644, compound → HCID 90426211, compound

HRID 2167677Notes

Reaction equation

HRID 2167677 reaction equation
[CH3:1][N:2]1[CH:10]=[C:9]2[C:4]([C:5]([C:12]#[N:13])=[CH:6][CH:7]=[C:8]2[CH3:11])=[N:3]1>CO.N.[Ni]>[CH3:1][N:2]1[CH:10]=[C:9]2[C:4]([C:5]([CH2:12][NH2:13])=[CH:6][CH:7]=[C:8]2[CH3:11])=[N:3]1

Participants

5

Reactant 1

HCID 90427644HCID 90427644, compound

Product 1

HCID 90426211HCID 90426211, compound

Reagents, catalysts & solvents 3

HCID 935NickelCatalystHCID 222AmmoniaSolventHCID 887MethanolSolvent

Procedure

To a solution of 2,4-dimethyl-2H-indazole-7-carbonitrile (1 equiv.) in methanol and aq. ammonia solution (9:1), catalytic amount of Raney Nickel was added. Reaction mass was stirred at room temperature under hydrogen pressure (balloon pressure) for 2-5 h. On completion of reaction, it was filtered through celite bed and filtrate was concentrated under reduce pressure to afford the title compound (quant. yield).

Workup

  1. customReaction mass
  2. customOn completion of reaction, it
  3. filtrationwas filtered through celite bed and filtrate
  4. concentrationwas concentrated

Sources & evidence

ORD record
ord-2f5e19c347ae4385a30253accf0bd60c
Source dataset
uspto-grants-2015_06
Patent number
US09045477B2

Reaction notes

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