HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroacetaldehyde → HCID 90427811, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroacetaldehyde | HCID 33 | — |
| Reactant | 2-Amino-4,6-dimethyl-3-pyridinecarbonitrile | HCID 230471 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 90427811 | HCID 90427811 | 75% |
Reaction Steps
To a stirred solution of compound 2-amino-4,6-dimethylnicotinonitrile (1 equiv.) in water was added chloroacetaldehyde (55% aq. solution) (1.2 equiv.) and reaction was heated at 80 oC for 16 h. On completion, it was quenched by 1N NaOH till pH 8. Solid precipitated was filtered and vacuum dried to afford the title compound (75% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09045477B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-44a3673fc57c4ef3b2740055c7d326b1 |
| Source note | uspto-grants-2015_06 |