HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroacetaldehyde → 7-Methylimidazo[1,2-a]pyridine-8-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroacetaldehyde | HCID 33 | — |
| Reactant | 2-Amino-4-methylpyridine-3-carbonitrile | HCID 10396887 | — |
| Solvent | Water | HCID 962 | — |
| Product | 7-Methylimidazo[1,2-a]pyridine-8-carbonitrile | HCID 76849704 | 75% |
Reaction Steps
To a stirred solution of compound 2-amino-4-methylnicotinonitrile (1 equiv.) in water was added chloroacetaldehyde (55% aq. solution) (1.2 equiv.) and the reaction was heated at 80 oC for 16 h. On completion, it was quenched by 1N NaOH till pH 8. Solid precipitated was filtered and vacuum dried to afford the title compound (75% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09045477B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-1bd35f134caf407ea9519a2d6b665761 |
| Source note | uspto-grants-2015_06 |