2-Methyl-2H-indazole-7-carbonitrile → HCID 44119221, compound

HRID 2167684Notes

Reaction equation

HRID 2167684 reaction equation
[CH3:1][N:2]1[CH:10]=[C:9]2[C:4]([C:5]([C:11]#[N:12])=[CH:6][CH:7]=[CH:8]2)=[N:3]1>CO.N.[Ni]>[CH3:1][N:2]1[CH:10]=[C:9]2[C:4]([C:5]([CH2:11][NH2:12])=[CH:6][CH:7]=[CH:8]2)=[N:3]1

Participants

5

Reactant 1

HCID 441192602-Methyl-2H-indazole-7-carbonitrile

Product 1

HCID 44119221HCID 44119221, compound

Reagents, catalysts & solvents 3

HCID 935NickelCatalystHCID 222AmmoniaSolventHCID 887MethanolSolvent

Procedure

To a solution of 2-methyl-2H-indazole-7-carbonitrile (1 equiv.) in methanol and aq. ammonia solution (9:1), catalytic amount of Raney Nickel was added. Reaction mass was stirred at room temperature under hydrogen pressure (balloon pressure) for 2-5 h. On completion of reaction, it was filtered through celite bed and filtrate was concentrated under reduce pressure to afford the title compound (quant. yield).

Workup

  1. customReaction mass
  2. customOn completion of reaction, it
  3. filtrationwas filtered through celite bed and filtrate
  4. concentrationwas concentrated

Sources & evidence

ORD record
ord-08b61626b11249f295c4aeb7010332f1
Source dataset
uspto-grants-2015_06
Patent number
US09045477B2

Reaction notes

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