Ammonium Persulfate → HCID 86720743, compound

Participants

Reaction Conditions

Reaction Steps

To an aqueous (50 mL) solution of 2-cyanopyrazine (6.7 mL), 3,3,3-Trifluoro-2,2-dimethylpropionic acid (10 g) and ammonium peroxodisulfate (22 g) were added, then silver nitrate (16 g) was added, and the resultant was stirred at 80° C. for 8 hours. The reaction solution was subjected to extraction with ethyl acetate. The organic layer was dried over magnesium sulfate, and the desiccant was filtered off. Then, the solvent was distilled off under reduced pressure. The obtained residue was purified by silica gel column chromatography (OH-type silica gel; hexane/ethyl acetate-gradient elution=100/0→75/25) to obtain the title compound (0.28 g) as a pale yellow oil.

Provenance & Evidence