反应详情

温度

70 °C

To an ethanol (5.0 mL) solution of 1-(5-fluoropyridin-3-yl)ethanone (0.50 g), acetic acid (6.0 mL) was added, then a 20 to 30% hydrobromic acid/ethanol solution (1.0 mL) and bromine (0.30 mL) were added under ice cooling, and the resultant was stirred at 70° C. for 45 minutes. The reaction solution was concentrated under reduced pressure to obtain the title compound (1.30 g) as a faint orange solid.

1. concentrationThe reaction solution was concentrated under reduced pressure