Iodine → HCID 67491521, compound

Participants

Reaction Steps

To a solution of 0.398 g (2 mmol) 1-ethoxy-2,2,6,6-tetramethyl-piperidin-4-one in dry acetonitrile is added 0.297 g (3 mmol) trimethylsilyl cyanide and a catalytic amount of iodine. The solution is stirred at rt over night. The reaction mixture is extracted with ethyl acetate, washed with Na2CO3 solution and brine. The organic layer is separated, dried over Na2SO4, filtered and the solvent is removed under reduced pressure. A yellow oil was obtained and subsequently subjected to flash chromatography on silica gel using 4:1 hexane/ethyl acetate as eluent. The product was obtained as a pale yellow oil.

Provenance & Evidence