Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 89618808 | HCID 89618808 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 89618838 | HCID 89618838 | — |
Reaction Steps
(R)-4-((tert-butoxycarbonyl)amino)-1-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)piperidine-4-carboxylic acid (100 mg, 0.17 mmol) added to 4N HCl in Dioxane (5 mL) was stirred at 20-35° C. for 3 h. The reaction mixture was concentrated under reduced pressure to afford crude. The crude obtained was washed with diethyl ether and dried to afford 58 mg of the title compound as a pale brown solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09045479B2 |
|---|
| Source dataset | uspto-grants-2015_06 |
|---|
| ORD ID | ord-324c6ecafdfa4280a738b7399e5f8bd4 |
|---|
| Source note | uspto-grants-2015_06 |
|---|