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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2167770Generated: November 1, 2026

Hydrochloric Acid → HCID 89618838, compound

https://huagongshe.com/reaction/2167770

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantHCID 89618808HCID 89618808—
Solvent1,4-DioxaneHCID 31275—
ProductHCID 89618838HCID 89618838—

Reaction Conditions

Temperature27.5 °C

Reaction Steps

(R)-4-((tert-butoxycarbonyl)amino)-1-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)piperidine-4-carboxylic acid (100 mg, 0.17 mmol) added to 4N HCl in Dioxane (5 mL) was stirred at 20-35° C. for 3 h. The reaction mixture was concentrated under reduced pressure to afford crude. The crude obtained was washed with diethyl ether and dried to afford 58 mg of the title compound as a pale brown solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09045479B2
Source datasetuspto-grants-2015_06
ORD IDord-324c6ecafdfa4280a738b7399e5f8bd4
Source noteuspto-grants-2015_06