Acetyl chloride → HCID 67032412, compound

Participants

Reaction Conditions

Reaction Steps

Acetyl chloride (1.35 mL, 8.9 mmol) was added to ethanol (60 mL). The resulting solution was added to 2-[4-(2,6-dichloro-benzyloxy)-phenyl]-morpholine-4-carboxylic acid tert-butyl ester (1.54 g; 3.4 mmol), at RT. The resulting mixture was stirred at 60° C. for 3 hours, and subsequently, at RT for three days. The resulting suspension was concentrated in vacuo, and treated with iPr2O. The formed precipitate was collected by filtration and dried in vacuo to afford 2-[4-(2,6-dichloro-benzyloxy)-phenyl]-morpholine hydrochloride (1.31 g).

Provenance & Evidence