反应详情

A solution of 1-benzyl-1,4,7,10-tetraazacyclododecane (4 g; 0.015 mol) and dimethylformamide diethylacetal (6.88 g; 0.0467 mol) in benzene (40 ml) is heated at 80 C. and the azeotropic mixture ethanol-benzene is distilled away. When the conversion is ended, the solvent is evaporated under reduced pressure and the final product is obtained as a yellow oil (4.0 g). Yield 96%

1. distillationand the azeotropic mixture ethanol-benzene is distilled away
2. customthe solvent is evaporated under reduced pressure