Trifluoroacetic acid → HCID 67033017, compound

Participants

Reaction Steps

Phosphoric acid mono-{2-[2-(4-octyloxy-phenyl)-morpholin-4-yl]-ethyl}ester: A solution of phosphoric acid di-tert-butyl ester 2-[2-(4-octyloxy-phenyl)-morpholin-4-yl]-ethyl ester (0.69 g; 1.31 mmol) in TFA (3 mL) and CH2Cl2 (3 mL) was stirred at RT for 1 hour. Subsequently, the reaction mixture was concentrated in vacuo and the residue treated with iPr2O. The precipitate was collected by filtration and dried in vacuo overnight to afford phosphoric acid mono-{2-[2-(4-octyloxy-phenyl)-morpholin-4-yl]-ethyl}ester trifluoroacetic acid salt (0.42 g) 1H NMR (400 MHz, DMSO-d6) δ ppm 0.63-0.79 (m, 3H) 0.98-1.32 (m, 9H) 1.45-1.58 (m, 2H) 2.86-3.07 (m, 2H) 3.13-3.28 (m, 2H) 3.29-3.47 (m, 2H) 3.68-3.83 (m, 3H) 3.89-4.06 (m, 3H) 4.57 (d, J=10.53 Hz, 1H) 6.77 (d, J=8.43 Hz, 2H) 7.10 (d, J=8.43 Hz, 2H).

Provenance & Evidence