HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethylamine methanol → (s)-3-Nitro-4-((tetrahydro-2h-pyran-3-yl)methylamino)benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethylamine methanol | HCID 21877050 | — |
| Reactant | (r)-3-Nitro-4-((tetrahydro-2h-pyran-3-yl)methylamino)benzenesulfonamide | HCID 67126530 | — |
| Solvent | Carbon Dioxide | HCID 280 | — |
| Product | (s)-3-Nitro-4-((tetrahydro-2h-pyran-3-yl)methylamino)benzenesulfonamide | HCID 67126407 | — |
Reaction Steps
The racemic mixture of EXAMPLE 11A was resolved by chiral SFC on an AD column (21 mm i.d.×250 mm in length) using a gradient of 10-30% 0.1% diethylamine methanol in CO2 over 15 minutes (oven temperature: 40° C.; flow rate: 40 mL/minute) to provide the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09045475B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-6f275eac60f94bdebab5d8ac01c85a34 |
| Source note | uspto-grants-2015_06 |