Diisopropylethylamine → HCID 178461894, compound

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Reaction Steps

Prepared according to Procedure H using (1S)-1-(7-fluoro-2-(pyridin-3-yl)-quinolin-3-yl)ethanamine (0.067 g, 0.236 mmol), 6-chloropurine (0.044 g, 0.283 mmol, 1.2 eq) and DIEA (0.48 mmol, 2.0 eq) in n-butanol (3 mL). N-((S)-1-(7-fluoro-2-(pyridin-3-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine [PI3Kδ IC50=23 nM] was obtained after purification as a white solid. 1H-NMR (MeOD) δ ppm 8.99 (s, 1H), 8.57-8.65 (m, 2H), 8.33 (d, J=7.83 Hz, 1H), 8.16 (s, 1H), 8.08 (s, 1H), 7.85-7.96 (m, 2H), 1.62 (d, 3H), Mass Spectrum (ESI) m/e=402 (M+1).

Provenance & Evidence