HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2168027Generated: October 30, 2026
Diisopropylethylamine → HCID 86642506, compound
https://huagongshe.com/reaction/2168027
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | (3R)-(+)-3-(tert-Butoxycarbonylamino)pyrrolidine | HCID 1514397 | — |
| Reactant | 1,1-Difluoro-2-iodoethane | HCID 3833565 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86642506 | HCID 86642506 | — |
Reaction Steps
To a solution of (R)-tert-butyl pyrrolidin-3-ylcarbamate (500 mg) and 1,1-difluoro-2-iodoethane (618 mg) in N,N-dimethylformamide (6 mL) was added N-ethyl-N-isopropylpropan-2-amine (1.403 ml) and the mixture was stirred at 70° C. for 72 hours. The reaction mixture was concentrated and the crude product was purified on silica gel with methanol/dichloromethane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09045475B2 |
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| Source dataset | uspto-grants-2015_06 |
|---|
| ORD ID | ord-a79b3bec0eda4803bd9e1a330e01c1eb |
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| Source note | uspto-grants-2015_06 |
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