HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-[3-(Dimethylamino)propoxy]benzonitrile → 3-[4-(Aminomethyl)phenoxy]-N,N-dimethylpropan-1-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-[3-(Dimethylamino)propoxy]benzonitrile | HCID 11858362 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-[4-(Aminomethyl)phenoxy]-N,N-dimethylpropan-1-amine | HCID 21465384 | — |
Reaction Steps
4-(3-(Dimethylamino)propoxy)benzonitrile (300 mg) in methanol (20 mL) was treated with Raney nickel (wet, 1.5 g) under H2 (30 psi) for 4 hour. The insoluble material was filtered off and the filtrate was concentrated to provide the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09045475B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-0d3d4d386feb4faabda01e1db0770d9c |
| Source note | uspto-grants-2015_06 |