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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2168042Generated: October 31, 2026

tert-Butyl piperazine-1-carboxylate → (S)-tert-Butyl 1-(oxetan-3-yl)pyrrolidin-3-ylcarbamate

https://huagongshe.com/reaction/2168042

Reaction equation

Participants

RoleNameHCIDCharge
Reactanttert-Butyl piperazine-1-carboxylateHCID 143452—
Reactant4'-Chlorobiphenyl-2-carbaldehydeHCID 1393689—
Reactant3-OxetanoneHCID 15024254—
Product(S)-tert-Butyl 1-(oxetan-3-yl)pyrrolidin-3-ylcarbamateHCID 56604508—

Reaction Steps

The title compound was prepared by substituting (S)-tert-butyl pyrrolidin-3-ylcarbamate for tert-butyl piperazine-1-carboxylate and 3-oxetanone for 4′-chlorobiphenyl-2-carboxaldehyde in EXAMPLE 1A.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09045475B2
Source datasetuspto-grants-2015_06
ORD IDord-f5706e60b0ca43118383dbc752d9afe0
Source noteuspto-grants-2015_06