HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium triacetoxyborohydride → Ethyl 4-[cyclopropyl(oxetan-3-yl)amino]cyclohexane-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | 3-Oxetanone | HCID 15024254 | — |
| Reactant | Ethyl 4-(cyclopropylamino)cyclohexanecarboxylate | HCID 67126892 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Ethyl 4-[cyclopropyl(oxetan-3-yl)amino]cyclohexane-1-carboxylate | HCID 67126835 | — |
Reaction Steps
To a solution of EXAMPLE 329A (1.05 g) in dichloromethane (10 mL) was added oxetan-3-one (0.358 g) followed by sodium triacetoxyborohydride (1.05 g). The mixture was stirred overnight. The mixture was diluted with dichloromethane (300 mL) and washed with 2N aqueous NaOH, water, brine and dried over Na2SO4. Filtration and evaporation of the solvent gave the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09045475B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-d1259de40d734017975ef80877e33e24 |
| Source note | uspto-grants-2015_06 |