HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Cyclopropylamino)propionitrile → 4-((4-((2-Cyanoethyl)(cyclopropyl)amino)-1-fluorocyclohexyl)methoxy)-3-nitrobenzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Cyclopropylamino)propionitrile | HCID 143537 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | 4-((1-Fluoro-4-oxocyclohexyl)methoxy)-3-nitrobenzenesulfonamide | HCID 67126764 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-((4-((2-Cyanoethyl)(cyclopropyl)amino)-1-fluorocyclohexyl)methoxy)-3-nitrobenzenesulfonamide | HCID 67126827 | — |
Reaction Steps
To a solution of EXAMPLE 363B (200 mg) in dichloromethane (6 mL) was added 3-(cyclopropylamino)propanenitrile (64 mg) followed by sodium triacetoxyborohydride (184 mg). The mixture was stirred overnight. The reaction mixture was diluted with dichloromethane (400 mL) and washed with 2N aqueous NaOH, water, and brine. After drying over Na2SO4, the mixture was filtered and evaporation of the solvent gave the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09045475B2 |
| Source dataset | uspto-grants-2015_06 |
| ORD ID | ord-97238ef198aa4a61922cb6c3ab0df63e |
| Source note | uspto-grants-2015_06 |