2-[(Oxan-4-yl)oxy]-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile → HCID 71679191, compound

HRID 2168156Notes

Reaction equation

HRID 2168156 reaction equation
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[CH:8]=[C:9]([C:11]3[CH:20]=[CH:19][C:14]4[NH:15][C:16](=O)N[C:13]=4[CH:12]=3)[O:10][C:3]=12.[O:21]1[CH2:26][CH2:25][CH:24]([O:27][C:28]2[CH:35]=[CH:34][C:33](B3OC(C)(C)C(C)(C)O3)=[CH:32][C:29]=2[C:30]#[N:31])[CH2:23][CH2:22]1>>[N:15]1([C:14]2[CH:19]=[CH:20][C:11]([C:9]3[O:10][C:3]4[C:4](=[N:5][CH:6]=[CH:7][C:2]=4[C:33]4[CH:34]=[CH:35][C:28]([O:27][CH:24]5[CH2:23][CH2:22][O:21][CH2:26][CH2:25]5)=[C:29]([CH:32]=4)[C:30]#[N:31])[CH:8]=3)=[CH:12][CH:13]=2)[CH2:8][CH2:9][O:10][CH2:3][CH2:16]1

Participants

3

Reactant 2

HCID 671148332-[(Oxan-4-yl)oxy]-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrileHCID 89738876HCID 89738876, compound

Product 1

HCID 71679191HCID 71679191, compound

Procedure

from 5-(7-chloro-furo[3,2-b]pyridin-2-yl)-1,3-dihydro-benzoimidazol-2-one and 2-(tetrahydro-pyran-4-yloxy)-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzonitrile; HPLC/MS: 1.811 min, [M+H]=453;

Workup

  1. custom1.811 min, [M+H]=453

Sources & evidence

ORD record
ord-77bba5fe333e4700989b9035e626f87c
Source dataset
uspto-grants-2015_06
Patent number
US09045493B2

Reaction notes

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