Sodium Hydroxide → HCID 71679681, compound

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Reaction Steps

A solution of 4-{7-[3-cyano-4-(tetrahydro-pyran-4-yloxy)-phenyl]-furo[3,2-b]pyridin-2-yl}-benzoic acid ethyl ester (1.6 g, 3.42 mmol) in 50 ml ethanol and 1M NaOH (20 mL, 40.0 mmol) is stirred at room temperature for 14 h. Ethanol is removed in vacuum and the mixture acidified with 1M hydrochloric acid. The resulting precipitate is filtered off, washed with water and dried for 16 h; yield: 1.4 g 4-{7-[3-cyano-4-(tetrahydro-pyran-4-yloxy)-phenyl]-furo[3,2-b]pyridin-2-yl}-benzoic acid; HPLC/MS: 2.12 min, [M+H]=441;

Provenance & Evidence