Hydrochloric Acid → HCID 86710200, compound

Participants

Reaction Steps

4M HCl in dioxane (10 mL) was added to 1,1-dimethylethyl[1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinyl]carbamate D10 (1.39 g) and the mixture stirred at room temperature for 1.5 hour. The white precipitate was filtered off, washed with dioxane and then Et2O before it was dried in a vacuum oven to give D11 (1.149 g) as a white solid, 1H NMR (d6-DMSO) δ 12.60 (1H, brs), 8.36 (1H, s), 8.34 (2H, m), 7.35 (1H, s), 4.20 (3H, m), 3.40 (2H, dt), 2.37 (3H, s), 2.10 (2H, m), 1.80 (2H, m), MS(ES+) 232 [M+H]+.

Provenance & Evidence