Trifluoroacetic acid → HCID 67976197, compound

Participants

Reaction Steps

Trifluoroacetic acid (TFA) (5 ml) was added to a solution of 1,1-dimethylethyl[1-(5-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4-piperidinyl]carbamate D10 (580 mg, 1.313 mmol). The mixture was stirred at room temperature during one hour. The solvent was evaporated and purified using and SCX cartridge (5 g). The cartridge was washed sequentially with MeOH and then Ammonia in MeOH (0.5M and 1M). The washings with Ammonia in methanol 0.5M and 1M were combined and evaporated to give D11a (280 mg) as a white solid. LCMS [M+H][email protected] mins (2 minute run).

Provenance & Evidence